797 research outputs found

    Dietary modifications for infantile colic

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    Infantile colic can be defined as periods of inconsolable, unexplained, and incessant crying in a seemingly healthy infant that, quite understandably, leads to exhausted, frustrated, and concerned parents seeking to comfort their child (Landgren 2010). The prevalence of excessive crying varies according to the definition used although, most often, it peaks during the second month of life,with a prevalence of 1.5%to 11.9%(Reijneveld 2001).Traditionally, the definition of the condition was based on the rule of three (Wessel 1954): that is, unexplained episodes of paroxysmal crying for more than three hours per day, for three days per week, for at least three weeks. More recently a new definition has been proposed. It refers to a clinical condition of fussing and crying for at least one week in an otherwise healthy infant (Hyman 2006). Colic can be graded as mild, moderate, or severe, though there is no consensus for this classification. Colic can affect up to 10% to 30% of infants worldwide (Clifford 2002; Rosen 2007)

    Legislative Action to Improve the Fiscal Health of the United States and Reduce National Debt

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    Fiscally focused policymakers and policy influencers raise concern over the increasing national debt of the United States. While the nation entered the twenty-first century in a state of relative low debt, debt has increased continuously since 2007. Advocates for debt control describe how increased national debt negatively impacts economic growth, income growth, insurance rates, crisis preparedness, and national security. These concerns have been substantially amplified as debt itself has been substantially amplified during the COVID-19 pandemic, and passage of the CARES Act. This memorandum proposes and recommends implementation of the debt reducing RODEO Act. RODEO will permit additional borrowing during the current health crisis, utilize debt control mechanisms which build upon tools used in previous such policies, and enforce a long-term implementation schedule which minimizes negative economic impacts. Targets will aim at a reduction of two percent annually; enabling economic growth and controlled spending to meet goals without additional taxes or programmatic cuts. CBO anticipates the debt to GDP ratio will be 105% by the close of 2022. The fourth of five RODEO targets requires the debt to GDP ratio to be 69% as early as 2046, or as late as 2060. The fifth target requires the ratio to be 60% by 2066. This gradual reduction of debt will create an enduring solution, improve the economic station and outcomes for citizens, and protect the position of the United States in the national stage

    Long-term 24-hour intraocular pressure control with travoprost monotherapy in patients with primary open-angle glaucoma

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    The aim of the study was to evaluate the long-term 24-hour intraocular pressure (IOP) efficacy of travoprost monotherapy in primary open-angle glaucoma patients

    Economia internazionale. Globalizzazione, produzione e occupazione

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    Il processo di globalizzazione dell’economia, ispirato ai principi della deregolamentazione e della flessibilità, ha costituito il carattere predominante del sistema delle relazioni economiche internazionali nella nostra epoca. Il presente testo nasce dall’idea di offrire uno strumento utile per la comprensione delle cause, dei meccanismi in azione e delle possibili conseguenze dei processi di liberalizzazione e di globalizzazione dei mercati. Benché la finalità del volume sia prevalentemente didattica, l’obiettivo è anche quello di fornire una prospettiva di lettura e di interpretazione degli epifenomeni della globalizzazione sufficientemente aperta anche ad una visione critica dei processi, degli assetti istituzionali e delle opzioni di politica economica e commerciale. Ciò soprattutto alla luce della evidente situazione di debolezza nella quale sembra versare oggi il modello di globalizzazione liberista, deregolata e senza governance che ha caratterizzato il sistema delle relazioni internazionali negli ultimi decenni

    CSF/serum matrix metallopeptidase-9 ratio discriminates neuro Behcet from multiple sclerosis

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    In neuro Behcet disease with multiple sclerosis-like features, diagnosis could be challenging. Here, we studied the cerebrospinal fluid and serum inflammatory profile of 11 neuro Behcet and 21 relapsing-remitting multiple sclerosis patients. Between the soluble factors analyzed (MMP9, TNF, IL6, CXCL13, CXCL10, CXCL8, IFN, IL10, IL17, IL23, and others) we found MMP9 increased in neuro Behcet serum compared to multiple sclerosis and decreased in cerebrospinal fluid. Furthermore, neuro Behcet analysis of circulating natural killer CD56(DIM) subset suggests their potential involvement in increased MMP9 production. We believe that these findings may have a translational utility in clinical practice
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